Preheat the oven to 425ºF and prepare a 9” X 13” baking dish with cooking spray.
Bring a larger pot of salted water to a rolling boil, and then add in the frozen vegetable mixture. Boil just until the vegetables are warmed through, about 2-3 minutes.
Drain the cooked vegetables in a strainer set over a sink. Set aside.
Add the cheddar cheese condensed soup, milk, garlic powder, onion powder, and black pepper to a large bowl and stir until well combined.
Add 1 ½ cups of the shredded cheddar cheese to the soup mixture and stir just until combined.
Add the drained vegetables to the soup and cheese mixture, and fold them in gently until they are completely coated.
Pour the vegetables into the prepared baking dish and top with the remaining ½ cup of shredded cheddar cheese.
Bake for 20-25 minutes, until heated through and bubbly.
Remove the casserole from the oven and sprinkle the crispy fried onions on top in an even layer.
Bake the casserole for an additional 5 minutes to crisp the onions, or broil for 1-2 minutes if your baking dish is broil-safe.
Remove from the oven and allow to cool for 5 minutes before serving.